We have designed a server to aid in the search for putative binding sites in 16S ribosomal RNA that could be targeted by peptide nucleic acid oligomers. You can browse all of the computed characteristics via the interactive plots in 16S rRNA and 23S rRNA bookmarks. While looking for the best rRNA sites we have computed multiple different characteristics of rRNA. The entire procedure, analyses and results are described in our publication. Please cite A. Górska et al., Scanning of 16S RNA for peptide nucleic acid targets, J. Phys. Chem. B, doi:10.1021/acs.jpcb.6b2082 if you find the server useful.

  • About this project

    The project goal was to select rRNA fragments as good targets for sequence-specific inhibition by nucleic acids' oligomers, specifically peptide nucleic acids. We searched for sites, which could be blocked by modified nucleic acids and their hybridization to rRNA would inhibit bacterial translation and further bacterial growth. This approach could help design oligomers targeted at specific bacteria, limiting the adverse effects of antibiotics therapy.

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